FTP not connecting!

Sometimes I got error , even when the PURE FTPD is on , the ftp connection will fail and I found new solution , I clicked on Save changes of PURE FTPD and then ftp will connect .
Always I got these error :
1-No connection could be made because the target machine actively refused it. Connection failed.

2-Timeout detected. (control connection)
Connection failed.

And now I mean right now I connect successfully with TLS/SSL Explicit encryption

Please help
Thanks